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Lyrica (Pregabalin)

Lyrica is an anticonvulsant and antiepileptic drug. The active component of the drug is pregabalin, which inhibits the movement of calcium into the cells of neurons in response to the potential action. The substance is characterized by a high degree of affinity to alpha-2-delta protein, located in the tissues of the central nervous system.

The use of the drug leads to a decrease in the release of neurotransmitters of pain in the synaptic slit when neurons are excited. As a result of such changes under the action of the drug, the impulse is selectively suppressed. However, Lyrica could have such an effect only in pathological conditions.

Lyrica has the properties of analgesic of neurotic and postoperative origin.

It does not provoke cancer.

The drug is well absorbed and begins to act within an hour after the reception. The drug is best taken on an empty stomach, since the drug concentration in plasma while taking with food is significantly reduced.

Withdrawal of the drug is carried out with urine.

Elderly people and those who suffer from impaired renal function require correction of the dose of the drug.

Indications for use

Lyrica is intended to relieve pain in fibromyalgia and neuropathic pain.

In addition, the drug is used to treat patients suffering from anxiety disorders, epileptic seizures. For the latter, the drug is indicated for both permanent treatments of epilepsy and partial seizures.


Lyrica is contraindicated in case of individual intolerance or hypersensitivity to any of the ingredients of the drug.

Do not use for the treatment of children under 12 years.

Particular attention in the appointment of the drug should be paid to pregnant and lactating women, as well as patients with renal dysfunction.

The period of pregnancy and breastfeeding

Data on the use of Lyrica in pregnant women are not enough. Therefore, it is recommended to carry out strict medical control during therapy with the drug during pregnancy before carefully weighing the risks and benefits.

It is best for women of reproductive age to exclude pregnancy and use reliable contraceptives.

Breastfeeding and drug therapy are incompatible.

Method of reception

Lyrica capsules are taken as a whole, by mouth. The pills should not be chewed or ground.

Lyrica is taken regardless of food, but more effective on an empty stomach.

The dosage is selected individually by the attending physician, depending on the characteristics of the patient, the nature of the disease, and the course of the disease.

The average recommended dose is 75 mg twice a day for neuropathic pain, epilepsy. The dose can be increased to 150 mg if needed, as well, twice a day.

If the patient is insensitive to the action of the drug or has a severe case, the initial dosage is 150 mg of the drug, which is doubled then. The interval between each dose raising should be at least a week.

The maximum allowable daily dose is 600 mg.

The duration of treatment depends on the effectiveness of treatment. You shouldn’t cancel the drug abruptly – gradually reduce the dosage to zero.

Patients with problems in the renal system dosage have dosages based on the level of creatinine clearance. The lower the ml/min ratio is, the lower the daily and initial doses will be.

Elderly people should check the functioning of the kidneys to determine the dosage. In the normal state, the dose is the same as for others.


Cases of drug overdose are not described. In an extreme case, it is possible to increase the side effects.

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